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LETI & CELLMIC Accelerate Adoption Of Biomedical Sensing

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In the above photo, Cellmic's digital imaging, lens-free microscope is ready to scan a tissue sample residing the the small petri dish that sits directly atop the CMOS image sensor. Photo courtesy of Cellmic and CEA-Leti.

Leti, a research institute at CEA Tech, and Cellmic, a company serving the healthcare industry through applications for smartphones and biophotonics, has announced that they have joined forces to accelerate the market adoption of lens-free imaging and sensing techniques by growing Leti's patent portfolio with a core patent from Cellmic.

Cellmic's key technology was pioneered by Aydogan Ozcan, UCLA's chancellor's professor, and his research group. This patented computational lens-free imaging approach reconstructs detailed images of specimens based upon their holographic shadows that contain unique 3D information; in healthcare applications samples typically include tissue sections, blood smears and cell cultures. The lens-free microscope is composed of a LED and a CMOS sensor. Recorded raw data are then reassembled with high resolution by utilizing holographic reconstruction algorithms. Cellmic, a UCLA spin-off, holds some of the core patents of this important computational imaging technique.

Cellmic and Leti stated that lens-free microscopy has emerged as a powerful imaging and sensing platform that developers believe may, by using dedicated algorithms, replace bulky and expensive optical components that are found in standard optical microscopy systems today. Leti developed a lens-free microscope in 2012. Today the technology offers an ultra-wide field-of-view, tracking more than 10,000 biological, microscopic objects at a time per image, providing lab techs with a cost-effective, highly compact and robust solution. The Cellmic patent complements Leti's IP portfolio and accelerates its ongoing valorization of its lens-free technology for diagnostics, biomedical sensing and related applications.

"Lens-free, on-chip imaging offers a very unique opportunity to bring advanced microscopy and sensing tools into your pocket with a fraction of the cost of existing technologies," said Ozcan, who is also a co-founder of Cellmic. "We are proud to have made fundamental contributions to establish this technique, which has been benefiting researchers in both academia and industry at a global scale."

"Our partnership with Leti will help this powerful imaging and sensing technology to reach different markets through Leti's powerful collaborations with other companies in various industries," added Neven Karlovac, the CEO and co-founder of Cellmic.

"Ozcan's research lab and Cellmic have done ground-breaking work in developing lens-free imaging techniques," said Jean-Marc Dinten, Leti Imaging department manager and international expert. "This core patent complements our lens-free technology development, such as point-of-care diagnosis for spinal meningitis."

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